A patient with sickle cell anemia has a valine substituted for glutamic acid. This change primarily disrupts which level of protein organization first?
Q1. A patient with sickle cell anemia has a valine substituted for glutamic acid. This change primarily disrupts which level of protein organization first?
Answer: Primary structure
Explanation: Sickle cell results from a single amino acid substitution in the primary sequence. Quaternary is tempting because hemoglobin has four subunits.