MDCAT Chemistry MCQ #256

A pharmaceutical company needs to determine the rate of metabolism of a certain phenol compound. Which step is typically the rate-determining step?

MDCAT Chemistry MCQ #256

  1. Question 1

    Q1. A pharmaceutical company needs to determine the rate of metabolism of a certain phenol compound. Which step is typically the rate-determining step?

    • A) Hydroxylation by cytochrome P450
    • B) Glucuronidation by UDP-glucuronosyltransferase
    • C) Sulfation by sulfotransferase
    • D) Acetylation by N-acetyltransferase

    Answer: Hydroxylation by cytochrome P450

    Explanation: Hydroxylation by cytochrome P450 fails due to the typically slower rate of glucuronidation compared to initial hydroxylation steps.