MDCAT Chemistry MCQ #320

During the base-catalyzed addition of HCN to acetone, what is the initial step that distinguishes it from an acid-catalyzed process?

MDCAT Chemistry MCQ #320

  1. Question 1

    Q1. During the base-catalyzed addition of HCN to acetone, what is the initial step that distinguishes it from an acid-catalyzed process?

    • A) Attack of a weak nucleophile
    • B) Protonation of the carbonyl oxygen
    • C) Attack of a strong nucleophile
    • D) Formation of a carbocation

    Answer: Attack of a strong nucleophile

    Explanation: Base-catalyzed mechanisms involve a strong nucleophile attacking the carbon, whereas acid-catalyzed mechanisms begin with protonation of the oxygen atom.