MDCAT Chemistry MCQ #339

In the base-catalyzed nucleophilic addition to a carbonyl group, the hydroxide ion reacts with the reagent to primarily increase what property?

MDCAT Chemistry MCQ #339

  1. Question 1

    Q1. In the base-catalyzed nucleophilic addition to a carbonyl group, the hydroxide ion reacts with the reagent to primarily increase what property?

    • A) The electrophilic nature of the carbonyl carbon
    • B) The nucleophilic character of the attacking reagent
    • C) The leaving group ability of the oxygen atom
    • D) The steric hindrance around the alpha carbon

    Answer: The nucleophilic character of the attacking reagent

    Explanation: Base-catalyzed mechanisms increase the nucleophilic character of the reagent. Acid catalysis is incorrect because it instead increases the electrophilicity of carbonyl carbon.