MDCAT Chemistry MCQ #371

In the acid-catalyzed nucleophilic addition to a carbonyl compound, what is the primary role of the acid catalyst during the initial step of the mechanism?

MDCAT Chemistry MCQ #371

  1. Question 1

    Q1. In the acid-catalyzed nucleophilic addition to a carbonyl compound, what is the primary role of the acid catalyst during the initial step of the mechanism?

    • A) Increase the nucleophilicity of the reagent
    • B) Increase the electrophilic character of carbonyl carbon
    • C) Decrease the polarity of the C=O bond
    • D) Stabilize the leaving group

    Answer: Increase the electrophilic character of carbonyl carbon

    Explanation: Acid catalysts protonate the carbonyl oxygen, making the carbon more electrophilic; base catalysts work by increasing the nucleophilic strength of the reagent.