MDCAT Chemistry MCQ #436

A student attempts an Aldol condensation with various carbonyl compounds. Which structural feature is absolutely necessary for the compound to react?

MDCAT Chemistry MCQ #436

  1. Question 1

    Q1. A student attempts an Aldol condensation with various carbonyl compounds. Which structural feature is absolutely necessary for the compound to react?

    • A) Presence of a beta-hydrogen
    • B) Absence of alpha-hydrogen
    • C) Presence of a gamma-hydrogen
    • D) Presence of an alpha-hydrogen

    Answer: Presence of an alpha-hydrogen

    Explanation: Aldol condensation requires at least one alpha-hydrogen to form the enolate ion. Benzaldehyde lacks this and undergoes Cannizzaro instead.